Rapid evaporative ionization mass spectrometry: A survey through 15 years of applications.
Abstract
Rapid evaporative ionization mass spectrometry (REIMS) is a relatively recent MS technique explored in many application fields, demonstrating high versatility in the detection of a wide range of chemicals, from small molecules (phenols, amino acids, di- and tripeptides, organic acids, and sugars) to larger biomolecules, that is, phospholipids and triacylglycerols. Different sampling devices were used depending on the analyzed matrix (liquid or solid), resulting in distinct performances in terms of automation, reproducibility, and sensitivity. The absence of laborious and time-consuming sample preparation procedures and chromatographic separations was highlighted as a major advantage compared to chromatographic methods. REIMS was successfully used to achieve a comprehensive sample profiling according to a metabolomics untargeted analysis. Moreover, when a multitude of samples were available, the combination with chemometrics allowed rapid sample differentiation and the identification of discriminant features. The present review aims to provide a survey of literature reports based on the use of such analytical technology, highlighting its mode of operation in different application areas, ranging from clinical research, mostly focused on cancer diagnosis for the accurate identification of tumor margins, to the agri-food sector aiming at the safeguard of food quality and security.
Cited in this thesis
Frequently Cited Together
- Minimally Invasive Evaluation of Venous Leg Ulcers in an Outpatient Setting Usin2 chapters
- Fishers' preference for mobile traceability platform: challenges in achieving a 2 chapters
- One model to learn them all2 chapters
- Melbourne restaurant hunky dory accused of serving catfish to customers instead 2 chapters
- Identification of the Species of Origin for Meat Products by Rapid Evaporative I2 chapters
- A simple framework for contrastive learning of visual representations2 chapters
BibTeX
@article{Cafarella2024,
title = {Rapid evaporative ionization mass spectrometry: A survey through 15 years of applications},
author = {Cafarella, Cinzia and Mangraviti, Domenica and Rigano, Francesca and Dugo, Paola and Mondello, Luigi},
journal = {Journal of Separation Science},
volume = {47},
number = {9-10},
pages = {2400155},
year = {2024},
publisher = {Wiley Online Library},
abstract = {Rapid evaporative ionization mass spectrometry (REIMS) is a relatively recentMS technique explored in many application fields, demonstrating high ver-satility in the detection of a wide range of chemicals, from small molecules(phenols, amino acids, di- and tripeptides, organic acids, and sugars) to largerbiomolecules, that is, phospholipids and triacylglycerols. Different samplingdevices were used depending on the analyzed matrix (liquid or solid), resultingin distinct performances in terms of automation, reproducibility, and sensitivity.The absence of laborious and time-consuming sample preparation proceduresand chromatographic separations was highlighted as a major advantage com-pared to chromatographic methods. REIMS was successfully used to achieve acomprehensive sample profiling according to a metabolomics untargeted anal-ysis. Moreover, when a multitude of samples were available, the combinationwith chemometrics allowed rapid sample differentiation and the identificationof discriminant features. The present review aims to provide a survey of literaturereports based on the use of such analytical technology, highlighting its mode ofoperation in different application areas, ranging from clinical research, mostlyfocused on cancer diagnosis for the accurate identification of tumor margins, tothe agri-food sector aiming at the safeguard of food quality and security.},
}